Cerebral leptomeningeal metastasis in a case of primary ovarian lymphoma

Nejmi Kiymaz¹*, Nebi Yilmaz¹, Mustafa Kösem², Taner Yazici¹, Suleyman Alici³ and Abdulbaki Kozan¹

¹Department of Neurosurgery, University of Yuzuncu Yil, School of Medicine, Van, Turkey.

²Department of Pathology, University of Yuzuncu Yil, School of Medicine, Van, Turkey.

³Department of Medical Onkology, University of Yuzuncu Yil, School of Medicine, Van, Turkey.

*Corresponding author. E-mail: nejmikiymaz@yahoo.co.uk.

Tel: 90.432.2164710/204190.532.4160980. Fax: 90.432.2167519.

Accepted 13 January, 2010

   Abstract

A 38 years old female patient is presented who applied to our neurosurgery clinic due to symptoms such as headache, ataxia, vertigo, vomiting and complaints related to a mass at the back side of her head. The examination of cranial magnetic resonance imaging (MRI) of the patient displayed a mass which obliterates the transverse sinus and extends from the scalp to the epidural space at a certain distance and to the occipital zone. The result of the biopsy report revealed an infiltration of malign lymphoma. The patient received cyclophosphamide, adriablastine, vincristine and prednisolone for 1 - 5 days, at 21 days interval and as 6 cures. A complete response was obtained at the end of the 3 rd cure. The patient was orientated for radiotherapy at the end of the sixth cure. This case is a rarely seen ovarian lymphoma and constitutes a sample for cerebral leptomeningeal metastasis which is a very rare condition.   

Key words: Cerebral leptomeningeal metastasis, primary ovarian lymphoma.