Prediction of 3D structure of P2RY5 gene and its mutants via comparative homology modelling

Samina Bilal¹, Hina Iqbal¹, Farida Anjum² and Asif Mir¹*

¹Department of Biosciences, Comsats Institute of Information Technology, Bio-Physics Block, Chak Shahzad Campus, Islamabad-44000, Pakistan.

²Pakistan Council for Science and Technology, Islamabad-44000, Pakistan.

*Corresponding author. E-mail: asif_mir@comsats.edu.pk .

Tel: +92-323-5022292

Accepted 21 October, 2009

   Abstract

3-D Structure of proteins gives valuable insights into the molecular organization, function, docking simulations and also effective drug designing experiments. Autosomal recessive hypotrichosis is a genetic hair disorder that is though not life threatening but it can lead to abhorrent effect on person’s psyche. In the lack of an experimentally determined structure, comparative or homology modeling can provide valuable 3D models. Most recently, mutations in the P2RY5 gene have been identified as a cause of Autosomal recessive hypotrichosis in families of different origin. Current study encompasses broad analysis of alterations brings by mutations in P2RY5 gene through Bioinformatics tools and determination of 3D structure of P2RY5 gene product using comparative modeling approach.

Key words: Comparative homology modeling, P2RY5, ramachandran plot, 3D model, protein modeling, bioinformatics, LAH3.