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Efficacy and toxicity of
cymelarsan® in Nubian goats infected with
Trypanosoma evansi
F. M. Youssif1*,
O. S. A. Mohammed2
and T. Hassan3
2Department of Medicine, Pharmacology and Toxicology- Faculty of
Veterinary Medicine.
Sudan
University
of Science and Technology. P. O. Box 407,
Sudan.
*Corresponding author. E-mail:
rozavet@yahoo.com and rozavet@gmail.com.
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Nine groups
of Nubian goats were infected with T. evansi. Groups
1 and 2 were used as negative and positive control
respectively, groups 3, 4, 5 and 6 were given a single
intramuscular dose of Cymelarsan® at the rate of
0.125, 0.25, 0.625, 1.25 mg/kg, respectively. Goats in
groups 7 and 8 were each given intramuscular Cymelarsan®
at the rate of 0.125 mg/kg twice/week for two weeks
and 0.125 mg/kg daily for 8 days, respectively. Goats in
groups 9 and 10 were each given the drug intramuscular at
the rate of 0.25 mg/kg twice/week for two weeks and 0.25
mg/kg daily for 8 days respectively. Goats in group 2 showed
clinical signs of trypanosomosis while infected goats of
groups (4 - 5) signs disappeared. Goats of group 3 responded
to the treatment but relapse occurred. Goats of groups (6 -
10) were parasite free but expressed clinical signs of
arsenic toxicosis. The haematological and serobiochemical
changes were correlated with the clinical signs and
pathology. Single dosages of 0.25 – 0.625 mg/kg wee
recommended for treatment of T. evansi. Single dosage
of 1.25 mg/kg and the multiple dosages were toxic and fatal.
The drug has accumulative effect.
Key
words: Nubian
goats, Cymelarsan, efficacy, toxicity, T. evansi,
Sudan. |
