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A study on antibody-mediated
enhancement of caprine arthritis encephalitis virus in goat
synovial membrane cells
Adebayo, I. A.
Department of Animal Production and Health, Federal
University of Technology, P. M. B 704, Akure, Nigeria.
*Corresponding
author. E-mail:
adebayoick@yahoo.com.
Accepted 7
January 2008
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Antibody-mediated enhancement of
caprine arthritis encephalitis (CAE) virus in goat synovial
membrane (GSM) cells was investigated with regards to time
of onset and severity of lesions. Homologous antibody was
serially diluted to enhance the growth of the virus as this
provided both optimal and subnormal concentrations of the
antibody. The cells were incubated for five days and later
stained with Giemsa stain. Marked cytopathic effects (CPE)
were observed early at sub-optimal concentrations of the
antibody indicating that the virus was enhanced at these
concentrations. Possible epidemiological implications of
these are discussed with relevance to the pathogenesis of
retrovirus infections in man and animals.
Key words: CAEV, GSM
cells, antibody-mediated enhancement, cytopathic effects.
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