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Biochemical effectiveness in
liver detoxication of fresh pineapple (Ananas comosus)
with the wistar rats, previously intoxicated by Doliprane®
Dougnon T. Jacques*, Kpodekon T. Marc
and Adjagba Marius
Research
Laboratory of Appliqued Biology (LARBA), University of
Abomey-Calavi (UAC), 01 Box 2009 Cotonou, Bénin.
*Corresponding
author. E-mail:
dougnonj@yahoo.fr.
Accepted 28
January 2008
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The effect of hepatic detoxication with the help of fresh
pineapple (Ananas comosus), was evaluated on
28 wistar albinos rats previously intoxicated by DOLIPRANE®
containing 20% of paracetamol. Four batches consisting, each
them of 7 animals were formed. Batch n° 1, was neither
intoxicated nor treated. Batch n° 2 was intoxicated for 2
weeks at the rate of two two (2) grams of DOLIPRANE® per
kilogramme of live weight per day,
then
treated for 4 weeks with 13 mg
of fresh pineapple per kg of live weight per day. Batch n°3
was intoxicated in the same way as batch n°2, but received
26 mg of fresh pineapple during 4 weeks. Batch n°4, was
intoxicated for two weeks with the same daily amount of
DOLIPRANE® and did not receive any treatment with pineapple.
The rates of Alkaline Phosphatase (ALP), Glutamate
Oxaloacetic Transaminase (GOT) and Glutamate Pyruvate
Transaminase (GPT) enzymes were ganged. As for batch n°4,
the values of those enzymes underwent a highly significant
increase on the threshold of 0.1% when compared with the
other three batches. ALP concentrations decreased from
406.67 ± 7.17 to 223.67 ± 3.28 for batch n°2 after the
treatment with the pineapple. Concerning the GPT, value
significantly decreased, passing from 242.67 ± 31.67 to 106
± 2.31 for batch n° 2. As for the GOT, its rate passed from
184.67 ± 3.75 to 117.33 ± 2.73 for batch n°2, without any
significance level on the threshold of 5%, comparing batches
n° 2 and n°3. It emerges from this study that overdosing of
DOLIPRANE® (2 g/kg of live weight) affected the biochemical
level, the normal functioning of the liver of the wistar
rats intoxicated per os. Fresh pineapple had a
reconstructive effect on the hepatic metabolism of the
intoxicated rats.
Key words: Liver detoxication, pineapple, DOLIPRANEŇ,
enzymes, wistar rats.
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