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Full Length Research Paper
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High
prevalence of multi-drug- resistance (MDR) and extended
spectrum β-lactamases (ESBL) producing bacteria among
community-acquired urinary tract infections (CAUTI)
Habeeb Khadri* and Mohammad Alzohairy
Department of
Medical Laboratories, College of Applied Medical Sciences,
Qassim University, Qassim, Kingdom of Saudi Arabia.
*Corresponding author. E-mail:
hkhadri@yahoo.com. Tel:
00966-3800050-ext-4171, 00966-564224431.
Accepted 18 December, 2009 |
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Abstract
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Urinary tract
infection (UTI) remains to be the most common infection
diagnosed in outpatients as well as in hospitalized patients.
Appropriate knowledge on the current antimicrobial
susceptibility pattern of uropathogen is essential for
appropriate therapy. Thus, a prospective study was carried out
in the Government Medical College and Hospital at Anantapur,
India from July - December, 2007 in order to determine the
frequency of multidrug resistance (MDR) and Extended-spectrum β-lactamase
(ESBL) producing uropathogens from community acquired urinary
tract infection (CAUTI). Of the 410 samples tested in this
study, 222 isolates showed significant bacterial growth among
which Escherichia coli strains was most prevalent (45%) followed
by Klebsiella spp (18%). Among gram negative bacterial isolates,
high prevalence of antibiotic resistance was observed against
Ampicillin, Norfloxacillin and Co-trimoxazole. 26% of strain
included in this study was found to be ESBL producer where MDR
is higher compare to non ESBL producer. Moreover Imipenem showed
a high potency and widest coverage against gram negative
isolates (100%). This presented study showed a high frequency of
antimicrobial resistance and ESBL production in
Enterobacteriaceae isolated from CAUTI patients in India.
Key words: Prevalence, UTI, multidrug resistance, ESBL.
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