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Fe(III)
and Co(II) complexes of mixed antibiotics: synthesis,
characterization, antimicrobial potential and their effect
on alkaline phosphatase activities of selected rat tissues
Ogunniran, K. O.1*, Ajanaku, K. O.1,
James, O. O.1, Ajani, O.O.1, Nwinyi,
C. O.2 and Allensela, M. A.3
1Department
of Chemistry, College of Science and Technology, Covenant
University, P. M. B. 1023, Ota, Ogun State, Nigeria.
2Department
of Biological Sciences, College of Science and Technology,
Covenant University, P. M. B. 1023, Ota, Ogun State, Nigeria.
3Chemistry
Department,
College of Education,
Benin, P. M. B 1144, Benin, Edo State, Nigeria.
*Corresponding author.
E-mail:
kennyrothy@yahoo.com.
Accepted 12 August, 2008 |
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Two new mixed ligand metal complexes of Fe(III)
and Co(II) chloride hexahydrate salts were prepared using
standard methods. Ampicillin trihydrate and oxytetracycline
hydrochloride antibiotics were used as ligands. Chemical
analysis including conductivity measurements, molecular
weight determination and spectroscopic studies were used to
propose the geometry and mode of binding of the ligands to
metal ions. Both ligands were proposed to coordinate to
metal ions in ratio 1:1:1 in the complexes. Each of the
ligands acted as terdentate ligand. Inhibition properties as
well as toxicity effect of administration of the metal
complexes at the dose of 3.33 mg/kg body weight thrice daily
for 5 days on the alkaline phosphatase (ALP) activities on
rat kidney, liver and serum were evaluated. The inhibitory
properties of the complexes were found to be significantly
different (P<0.05) at the concentration of 1%(w/v) as
compared to each of the ligands. The complexes were found to
significantly increase (P<0.05) alkaline phosphatase from
homogenates of liver and kidney tissues of the tested doses.
However there was no significant difference (P>0.05) in ALP
from liver and kidney sera. The results indicated that more
potent compounds with better physical properties and
enhanced antimicrobial activities upon complexation have
been prepared.
Key words:
Metal complexes, complexation, antibiotics, antimicrobial
properties, alkaline phosphatase. |
