|
HLA-DQA1 and –DQB1
genotyping in individuals with family history of gastritis
Nibras S. Al-Ammar1, Ihsan
Al-Saimary1*, Saad Sh. Hamadi2 and
Ma Luo2
1Department
of Microbiolody, College of Medicine, University of Basrah,
Basrah, Iraq.
2Department
of Medicine, College of Medicine, University of Basrah,
Basrah, Iraq.
*Corresponding author. E-mail:
ihsanalsaimary@yahoo.com.
Accepted 15 April, 2011 |
|
The objective
was to study HLA-DQA1 and HLA-DQB1 genotyping in individuals
(patients and controls) with family history of gastritis.
This study was carried out in College of Medicine,
University of Basrah. HLA-DQA1 and HLA-DQB1 genotyping was
done in College of Medicine, University of Manitoba, and
Winnpeg, Canada during the period from 17th of April 2009 to
15th of July 2010. A total of 100 patients (41 males and 59
females) and a total of 30 controls (18 males and 12
females) were included in this study. A significant
decreased frequency of DQA1*0201 allele was found in
individuals (patients + controls) with family history of
gastritis with a strong association (odds ratio = 4.57), as
compared with individuals without family history of
gastritis. Significant increased alleles frequencies of
DQA1*0402 and DQB1*0402 were found in individuals with
family history of gastritis, but with weak association (odds
ratios, 0.16 and 0.20 respectively), as compared with
individuals without family history of gastritis.
Key words:
HLA-DQA1, HLA-DQB1, genotyping and gastritis. |
