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Transition metal complexes as potential therapeutic agents
Shazia Rafique*, Muhammad Idrees, Anwar Nasim, Haji Akbar
and Amin Athar
National Centre of Excellence in Molecular Biology,
University of the Punjab, Lahore 53700, Pakistan.
*Corresponding author. E-mail:
shaziarafique@gmail.com.
Accepted 2 March, 2010 |
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Transition metals have important place within medicinal
biochemistry. Research has shown significant progress in
utilization of transition metal complexes as drugs to treat
several human diseases like carcinomas, lymphomas, infection
control, anti-inflammatory, diabetes, and neurological
disorders. Transition metals exhibit different oxidation
states and can interact with number of negatively charged
molecules. This activity of transition metals has started
the development of metal-based drugs with promising
pharmacological application and may offer unique therapeutic
opportunities. To provide an update on recent advances in
the medicinal use of transition metals, a Medline search was
undertaken to identify the recent relevant literature.
Key words:
Transition metals, metal complexes, anticancer drugs, metal
therapeutics. |
