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Performance of
starch obtained from Dioscorea dumetorium as
disintegrant in sodium salicylate tablets
Ibezim, Emmanuel C.1,
Ofoefule, Sabinus I2, Omeje, Edwin O3*
and Odo, U. E.4
1Department
of Pharmaceutics, University of Nigeria, Nsukka, Nigeria.
2Department
of Pharmaceutical Technology and industrial Pharmacy,
University of Nigeria, Nsukka, Nigeria.
3Department
of Pharmaceutical and Medicinal Chemistry, University of
Nigeria, Nsukka, Nigeria.
4Department
of Pharmacognosy, Faculty of Pharmaceutical sciences,
University of Nigeria, Nsukka, Nigeria.
*Corresponding author. E-mail: winnomeje@yahoo.com. Phone:
+234 80 35495441
Accepted 31 January 2008
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Starch obtained from Dioscorea dumetorium was
employed as a disintegrant in Sodium Salicylate based
tablets at concentrations of 5 –15 %w/w. Properties of the
starch evaluated include: bulk and tapped densities, water
uptake by capillarity, Hausner’s quotient and percent
compressibility. Compound tablets were evaluated for
hardness, friability, disintegration time and dissolution
rate. Batches of tablets containing equivalent
concentrations of AC-di-sol or maize starch were employed as
standards. Results obtained indicate that Dioscorea
dumetorium starch performed as much better as a
disintegrant in sodium salicylate tablets as maize starch
but less than Ac-di-sol.
Key words:
Disintegrant, starch, Dioscorea dumetorium, sodium
salicylate. |
