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Full Length
Research Paper
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Does alcohol
consumption increase the risk of severe adverse events to
ivermectin treatment?
Takougang I.1*,
Ngogang J.2, Sihom F.1, Ntep M.3,
Kamgno J.3, Eyamba A.4,
ZouréH.5,
Noma M.5 and Amazigo U. V.5
1Department
of Public Health, Faculty of Medicine and Biomedical
Sciences; University of Yaoundé 1, P. O. Box 1364 Yaoundé,
Cameroon.
2Department
of Physiological Sciences, Faculty of Medicine and
Biomedical Sciences, University of Yaoundé 1, P. O. Box 1364
Yaoundé, Cameroon.
3National
Programme for Onchocerciasis Control, Ministry of Public
Health, Yaoundé, Cameroon.
4Carter
Center/Global 2000, Yaoundé, Cameroon.
5African
Programme for Onchocerciasis Control, BP 155 Ouagadougou,
Burkina Faso.
*Corresponding
author:
E-mail:
itakougang@yahoo.com
Accepted June 2, 2008 |
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Abstract |
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The present investigation is a case-control study designed to
assess the level of association between alcohol consumption and
the occurrence of severe adverse reaction (SAE) following
ivermectin consumption. Thirty-six (36) cases
of SAE occurred in the health districts of Bankim, Nanga
Eboko, Obala, Okola and Sa’a.
Case and control (43)
individuals were submitted to a questionnaire related to their
alcohol consumption 24 before and 24 to 48 h following
ivermectin intake. An in-depth interview of siblings and local
health worker was conducted to assess alcohol consumption around
Mectizan intake. The degree of alcohol use was assessed using
the level of serum transaminases and the alcohol use disorder
identification test (AUDIT). The alcoholic beverages of the
study communities were conventional such as beer, whisky, or
locally made. Locally produced beverages included “arki”
(“Odontol”, “Hah”, ...) and palm wine. The bark, sap or fruit of
plants adjuvant are known to contain alkaloids and tannins which
are potent neurotropic substances. The likelihood of developing
SAE among cases and controls did not differ significantly with
history of consumption of alcoholic beverages. Nor did it differ
for other indicators of chronic alcohol consumption.
Key words:
Alcohol consumption, onchocerciasis, AUDIT, serious adverse
events, encephalopathy. |
