Effect of light irradiation on the antimicrobial activity of
Zanthoxylum zanthoxyloides (lam) methanolic extract
Olayemi Modupe Adegbolagun* and Oluwasola Omotayo Olukemi
Pharmaceutical Chemistry, Faculty of Pharmacy, University of
Ibadan, Oyo State, Nigeria.
Tel: 234 - 8023451393.
Accepted 23 February, 2010
The effect of
light irradiation on the antibacterial
potentials of methanol root extracts of
Zanthoxylum zanthoxyloides (Linn) was
evaluated against some clinical isolates of
gram-positive and gram-negative microorganisms
using the agar diffusion method. The methanol
extracts were exposed to three different sources
of radiations: sunlight (28 days), tungsten lamp
(72 h) and photoreactor (1 h, 365 nm) after
which their antibacterial activity was
determined. The colour of the extract monitored
by colour visualization and TLC revealed
significant colour changes for each treatment;
yellow to very light yellow (sunlight and
tungsten) while the photoreactor irradiated
sample did not show appreciable colour change.
The antibacterial activity of the extracts
generally reduces significantly (p < 0.05) after
exposure to the varied radiations. The results
in this study indicate a possible compromise of
the antimicrobial quality of herbal preparations
containing Z. zanthoxyloides; this
highlights the need for appropriate storage of
such herbal products.
Zanthoxylum zanthoxyloides, radiation,
antimicrobial activity, herbal products.
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