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Isolation,
characterization and antibacterial activity screening of
ethoxyamine tetrahydroxyanthocyanidines from Detarium
senegalense gmelin stem bark
Donatus Ebere Okwu* and Rosemary Uchegbu
Department of Chemistry, Michael
Okpara
University
of Agriculture, Umudike, P.M.B. 7267, Umuahia, Abia
State
Nigeria.
*Corresponding author. E-mail:
okwudonatus@yahoo.com.
Accepted
December 22, 2008 |
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Detarium senegalense
F. Gmelin (Leguminasae) is well-known Nigerian food and
medicinal plant, commonly used in phytomedicine to cure diseases and
heal injuries. The ethanol stem barks extract of D. senegalense
affords an anthocyanidin alkaloid (2-methoxyamine 3,4,5,7 – tetrahydroxy
anthocynadines). The structure was elucidated using NMR spectroscopy in
combination with IR and MS spectral data. Antibacterial studies showed
that the isolated compound successfully inhibited Staphylococcus
aureus, Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis
and Klebsiella pneumonia. This result authenticates the use of
the plant in phytomedicine for the treatment of infections, disease
prevention and as a preservative of local palm wine in South Eastern
Nigeria.
Keywords:
Detarium senegalense, anthocyanidin, alkaloid, antibacterial,
preservative, phytomedicine. |
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