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African Journal of
Microbiology Research Vol. 1 (6), 088-091,
November, 2007
ISSN 1996-0808 © 2007 Academic Journals
Full Length
Research Paper
Studies on immuno-bioactivities of Nyctanthes
arbortristis (Oleaceae)
M. Kannan1*, A.J.A. Ranjit Singh2,
T.T. Ajith Kumar3, P. Jegatheswari4
and S.Subburayalu5
1Microbiology Department,
V.H.N.S.N.College, Virudhunagar-626 001, India.
2Department of Biology, Sri
Paramakalyani College, Alwarkurichi–627412
India.
3CAS in Marine Biology, Annamalai
University, Parangipettai – 608 502, India.
4Dhanalakshmi Srinivasan College for
Women, Perambalur-621 212, India.
5K.R College of Arts and Science,
Kovil Patti – 628 503, India.
*Corresponding author. E-mail:
microkannan@gmail.com.
Accepted 31 October, 2007
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Abstract |
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In this study the
immunomodulatory potential of an Indian
medicinal plant, Nyctanthes arbor-tristis L.
(Oleaceae), was investigated. The leaf
extracts of N. arbor-tristis is used to
treat arthritis, lung injury and some painful
conditions such as cancer, chronic fever and
rheumatism. An ethanolic extract of N.
arbor-tristis (NAEE) was screened in rats
for humoral and cell-mediated immune responses.
Oral administration of the NAEE to rats at a
dose of 50, 100, 150 and 200 mg/kg significantly
enhanced the circulating antibody titre when
challenged with sheep red blood cells (SRBC) and
heat-killed Salmonella antigens. The
chronic administration of NAEE increased the
total counts of white blood cells (WBC) and
potentated the delayed-type hypersensitivity
(DTH) reactions. The present study confirms the
strong immuno-bioactivities in extracts of
Nyctanthes arbor-tristis L.
Key words: Immuno-bioactivities,
Nyctanthes arbor-tristis, anti inflammatory,
humoral immunity, delayed-type hypersensitivity. |
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