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African Journal of
Microbiology Research Vol. 1 (7),113-116,
December, 2007
ISSN 1996-0808 © 2007 Academic Journals
Full Length
Research Paper
Immunoglobulin profile of some Nigerians with
Schistosoma haematobium infection
O. P. G. Nmorsi1*,
N. C. D. Ukwandu2, C. Isaac1,
A. O. Egwunyenga3 and
N. H. Olague1
1Tropical
Diseases Research Unit, Department of Zoology,
Ambrose Ali University,
Ekpoma, Nigeria.
2Department
of Medical Microbiology, Ambrose Ali University,
Ekpoma, Nigeria.
3Department
of Zoology, Delta State University, Abraka,
Nigeria.
*Corresponding author.
E-mail: nmorsiopg@yahoo.com.
Accepted 13 December, 2007 |
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Abstract |
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The preliminary investigation
revealed the prevalence of 138(46.9%) out of 294
volunteers screened for the ova of
Schistosoma haematobium in their urine
samples. Of these, 84(28.6%) had light infection
(≤ 50 ova/10 ml urine), while 54(18.4%) had
heavy infection (> 50 ova/10 ml urine). This
difference was statistically significant at (χ2
= 6.52, p > 0.05). The mean immunoglobulin
status were as follow: IgE (2141.6 ± 143.7 ng/dL),
IgG (13.6 ± 3.53 mg/dL), IgA (3.72 ± 0.149 mg/dL),
IgM (2.82 ± 0.48 mg/dL) and IgD (0.12 ± 0.04 mg/dL).
The relationship between the IgM, IgE and the
intensities of infection were positively
correlated (r = 0.27 and r = 0.65,
respectively). IgG, IgA and IgD showed negative
correlation with the intensities of infection (r
= -0.65, r = -0.39 and r = -0.18, respectively).
IgG and IgA can be used as markers of light
infection, while IgM and IgE can be used as
markers for heavy infection. We deduced that the
levels of IgG, IgA and IgM, which were depleted
in the infected volunteers, compared to the
control subjects, which lacked significant
protective effects in these infected volunteers.
These low levels of IgA, IgG and IgM and high
level of IgE may be involved in maintenance of
S. haematobium infection in our study
area.
Key words:
IgA, IgD, IgE, IgG, IgM,
Schistosoma haematobium, Nigerians. |
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