|
Prevalence and
characterization of extended-spectrum beta-lactamase
production in clinical isolates of Klebsiella spp.
Rashid Ramazanzadeh
Microbiology Department, Faculty of Medicine, Kurdistan
University of Medical Science, Sanandaj, Iran. E-mail:
rashid@muk.ac.ir or
atrop_t51@yahoo.com.
Accepted 20 January, 2010 |
|
Extended-spectrum beta-lactamases (ESBLs) are most prevalent
in Klebsiella pneumoniae. This organism is frequently
isolated from clinical specimens and can cause septicemia,
pneumonia or urinary tract infection. We investigated a
spread of Klebsiella spp. isolates producing
ESBL in a university hospital of Sanandaj-Iran. Over
one year period, a total of 48 K. pneumoniae
isolates, were examined by double disk tests and PCR
methods. Ten isolates were defined as ESBLs. The ESBL
producer isolates was more resistant to selected antibiotics
than ESBL negative isolates. The most frequent ESBL type was
CTX-M. This is the first report of Klebsiella spp.
isolates producing ESBL in Sanandaj hospitals. Production of
ESBLs by K. pneumoniae is a widespread
nosocomial problem. Knowledge about their prevalence is
essential to guide towards appropriate infection control and
antibiotic management strategies.
Key words:
Extended-spectrum β-lactamase (ESBL), hospital,
Klebsiella spp. |
