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A taurine phenolic
compound (TPC) protect from AAP hepatotoxicity through
involvement of Nrf2/ARE pathway
Qiu Feng* and He Xiao-Jing
Department of Pharmacy, Sheng jing Hospital of China Medical
University, Shenyang 110004, People’s Republic of China.
*Corresponding author. E-mail:
qiuf@sj-hospital.org.
Tel: 86-24-
96615-71111.
Accepted 16 June, 2010 |
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Oxidative stress is a main contributor to the hepatotoxic
effects of acetaminophen, the Nrf2/ARE pathway has been
characterized as an important endogenous mechanism for
combating oxidative stress. Taurine plays various important
roles in a large number of physiological and pathological
conditions in human body, such as the antioxidant,
anti-inflammatory effects. It proves that phenol compound
has antioxidant effect through involvement of Nrf2/ARE
pathway. The taurine phenolic compound (TPC) we synthesized
belongs to phenolic compounds and we have reported that a
TPC protect from AAP hepatotoxicity. We thus hypothesize the
protective effects of TPC in an acute chemical model of
acetaminophen-induced hepatotoxicity through involvement of
Nrf2/ARE pathway.
Key words:
TPC, AAp, hepatotoxicity, Nrf2/ARE and hypothesis. |
