|
Antiviral effect of Hibiscus sabdariffa and
Celosia argentea on measles virus
Omilabu A. Sunday1*, A. Bankole Munir5,
O. Oyefolu Akeeb3, A. Adesanya Bolanle2
and S. O. Badaru4
1Department
of Medical Microbiology and Parasitology, College of
Medicine, University of Lagos, Akoka, Lagos, Nigeria.
2Department
of Botany and Microbiology, University of Lagos, Akoka,
Lagos, Nigeria.
3Department
of Microbiology, Lagos State University, Ojo, Lagos,
Nigeria.
4Central
Public Laboratory, Ministry of Health, Yaba, Lagos, Nigeria.
5Ministry
of Health Lagos State, Ikeja, Lagos, Nigeria.
*Corresponding author. E-mail:
Bankka2000@yahoo.com,
omilabusa@yahoo.com
Accepted 17 December, 2009 |
|
Studies on
extracts and biologically active compounds isolated from
medicinal plants have doubled in the last two decades. The
leaves of Hibiscus sabdariffa (red and green leaved)
and Celosia argentea were studied for their antiviral
activities against Measles Virus (MV) as well as the effects
of the extracts on Hep-2 cells. Ethanol extract of the
leaves of each of these plants showed no toxicity to the
Hep-2 cells at all concentrations used (5, 10 and 15 mg/ml).
The pre-inoculative treatment of Hep-2 cells with plant
extracts showed that C. argentea had no antiviral
activities on MV at all concentrations (5, 10, 15 mg/ml)
while H. sabdariffa had antiviral activities only at
10 and 15 mg/ml on MV. The post-inoculative treatment of
Hep-2 cells with plant extracts showed that at 5, 10 and 15
mg/ml concentrations, H. sabdariffa had antiviral
activities on MV while the antiviral activity of C.
argentea could not be established at 10 and 15 mg/ml but
did not show any antiviral activity at 5 mg/ml.
Key words:
Hibiscus sabdariffa, Celosia argentea,
antiviral, toxic, Hep-2 cell, herb, medicinal plant. |
