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Modulation of di- (2-
ethylhexyl) phthalate induced hepatic toxicity by Apium
graveolens L. seeds extract in rats
G. C. Jain,* Hemant Pareek, B. S. Khajja, Kusum Jain, S.
Jhalani, S. Agarwal and Sameer Sharma
Reproductive Physiology Section, Department of Zoology,
University of Rajasthan, Jaipur - 302004, India.
*Corresponding author. E-mail:
jain_gc@yahoo.co.in
. Tel.: +91-141-2369747
Accepted
27 April,
2009 |
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In the present study, the hepatoprotective activity of
methanolic extract of Apium graveolens L. (celery)
seeds was tested against Di-(2-
ethylhexyl) phthalate
(DEHP) induced hepatotoxicity in rats. Oral administration of DEHP
(1000 mg/kg b.wt/day) for 6 weeks in rats caused a
significant increase in the levels of serum marker enzymes
like serum glutamate oxaloacetate transaminase (SGOT), serum
glutamate pyruvate transaminase (SGPT), alkaline
phosphatases (ALP) and the levels of total
bilirubin and hepatic lipid peroxidation (TBARS).
The levels of serum protein, hepatic glutathione (GSH) and
ascorbic acid were decreased, administration of A.graveolens seeds extract
(300 mg/kg b.wt./day p.o.) for 6 weeks results in a significant recovery
of these biochemical parameters toward normalcy compared
with the DEPC treated and control rats.
Key
words: Apium
graveolens, hepatic toxicity,
di-(2-
ethylhexyl) phthalate,
hepatic marker enzymes |
