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Effects of ivermectin and
albendazole on some liver and kidney function indices in
rats
R. O. Arise* and S. O. Malomo
Department of Biochemistry, Faculty of Science,
University
of Ilorin, P. M. B. 1515, Ilorin, Kwara State, Nigeria.
*Corresponding author. E-mail:
arisedshine@yahoo.com
.
Accepted
30 April,
2009 |
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Evaluation
of repeated administration of ivermectin and albendazole
separately and in combination on some hepatic and renal
function indices were examined in albino rats (Rattus
novergicus). The experimental animals were randomly
divided into four groups: those administered distilled water
(control), those administered 0.4 mg/kg bodyweight of
ivermectin (Iver), those administered 15 mg/kg body weight
of albendazole (Alb) and those administered the two drugs
concurrently (Iver+Alb). The animals were administered, the
drugs daily for fifteen days after which venous blood, liver
and kidney were collected. The separate administration of
ivermectin and albendazole significantly elevated (P<0.05)
the concentrations of serum potassium and bicarbonate ions.
Also, their co-administration caused a significant elevation
(P<0.05) of serum phosphate ion concentration.
Administration of ivermectin and/or albendazole led to
significant increase (P<0.05) in serum urea, creatinine,
glucose and cholesterol concentrations while albumin was
significantly reduced (P<0.05). Generally, activities of
ALP, ACP, LDH, AST, ALT, Na+-K+ ATPase
and Ca2+-Mg2+ ATPase of liver and
kidney were significantly altered (P<0.05). These
observations may be suggestive of deranged membrane
structures and functions. Thus the combined administration
of the two drugs may be exerting more deleterious effects on
both renal and hepatic functions than when administered
individually.
Key words:
Ivermectin, albendazole, liver function, kidney function. |
