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Toxicological studies of
Ceiba pentandra linn
S, Sarkiyayi1,
S. Ibrahim1 and M. S. Abubakar2
1Department
of Biochemistry A. B. U. Zaria, Nigeria.
2Department
of Pharmacognocy and Drug development ABU Zaria, Nigeria.
*Corresponding author. E-mail:
sarkiyayi_shehu@yahoo.com.
Accepted 1
July, 2009 |
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The
toxicity profile of aqueous methanol extract of Ceiba
pentandra leaves was investigated in mice. Two
parameters were determined; acute toxicity and chronic
toxicity. For acute toxicity test, the LD50 was
found to be over 5000 mg/kg. For
chronic toxicity test, the mice were injected with graded
doses (250 - 500 mg/kg) of the leaves extract daily for 21
days and the effects on body weight, hematological and serum
biochemical parameters were determined. The results revealed
that there was no significant change in body weight, meaning
that the extract is relatively safe for oral medical use. In
fact there were no variable changes in the body weight of
the mice from day zero (D0) to day twenty one (D21)
in all the groups. The parameters determined during chronic
toxicity test reveals that the concentrations of urea,
chloride ion sodium ion ,potassium ions and bicarbonate were
11.2, 83.2, 131.6, 8.44 and 38 mMol/L respectively for the
test animals .The result shows that apart from urea,
all other parameters were within physiological acceptable
range. The results further reveals, that there was a
decrease in Craetinine (88 uMol/L) and Total Protein (57.4
g/L), while AST (19 IU/L), ALT (10 IU/L) and ALP (204 IU/L)
concentrations has significantly increased .While there was
no significant change in PCV and Bilirubin concentrations
The finding reveals that Ceiba pentandra has very low
toxicity profile in all the tested animals and the plant is
relatively safe for herbal oral medication.
Key words:
Ceiba pentandra,
toxicity, plant. |
