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Hepatoprotective effect of
Cichorium intybus on
CCl4-induced
liver damage in rats
Sadeghi Heibatollah1*, Nikbakht Mohammad Reza2;
Ghaitasi Izadpanah2 and Sabzali Sohailla3
1Department
of Biochemistry, Faculty of Medicine, Yasuj University of
Medical Sciences, Yasuj –Iran and Herbal Medicine Research
Center, Yasuj University of Medical Sciences, Yasuj –Iran.
2Department
of Physiology and Pharmacology, Faculty of Medicine, Yasuj
University of Medical Sciences, Yasuj –Iran and Herbal
Medicine Research Center, Yasuj University of Medical
Sciences, Yasuj –Iran.
3Imam
Sajjad Hospital, Yasuj University of Medical Sciences, Yasuj,
Iran.
*Corresponding author.
E-mail:
hsadeghim@yahoo.com.
Tel: +98-741-2233699. Fax: +98-741-2233704.
Accepted
11 April, 2008 |
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The purpose
of this study was to evaluate the hepatoprotective activity
of hydroalcholic extract of Cichorium intybus (Cichorium
intybus) using a carbon tetrachloride (CCl4)
- induced liver injury in rats.
The leaf
extract at oral dosage of 200, 400 and 500 mg/kg exhibited
significant (P<0.05) protective effect against CCl4
induced hepatoxocity. Level of serum markers such as
aspartate aminotransferase (AST), alanine aminitransferase
(ALT), alkaline phosphatase (ALP), total bilirubin (TB) were
significantly increased in CCl4 treated rats.
Simultaneously, C. intybus extract significantly
suppressed mainly the increase in plasma activities of AST,
ALT, ALP and TB concentration, which are considered as
markers of liver functional state. The results of this study
confirmed the hepatoprotective activity effect of the
hydroalcholic extract of C. intybus.
Key
words:
Cichorium intybus, hepatoprotective activity, carbon
tetrachloride, aspartate aminotransferase, alanine
aminitransferase, alkaline phosphatase. |
