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Effect of
administration of aqueous and ethanolic extracts of
Enantia chlorantha stem bark on brewer’s yeast-induced
pyresis in rats
Adesokan, A. A.1*, Yakubu,
M. T.1, Owoyele, B. V.2, Akanji, M. A.1,
Soladoye, A. O.2 and Lawal, O. K.2
1Department
of Biochemistry, Faculty of Science,
University
of Ilorin, Ilorin, Nigeria.
2Department
of Physiology, College of Health Sciences, University of
Ilorin, Ilorin, Nigeria
*Corresponding author. E-mail:
tomuyak@yahoo.com;
adesokan_ayoade@yahoo.com
GSM: +234-8033608498.
Accepted
15 May 2008 |
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The phytochemical screening of aqueous and ethanolic
extracts of the stem bark of Enantia chlorantha Oliv
as well as the antipyretic effect of the solvent extracts at
25, 50, 100 and 200 mg/kg body weight was investigated in
albino rats. Phytochemical analysis of the aqueous and
ethanolic extracts of E. chlorantha stem bark
revealed the presence of phenolics, flavonoids, alkaloids,
glycosides and saponins. The concentrations of these
phytochemicals in the ethanolic extracts were slightly
higher than in the aqueous extracts. The 50 - 200 mg/kg body
weight of the solvent extracts produced significant
reduction (P<0.05) in rectal temperature of the hyperpyretic
rats. The antipyretic activities of the solvent extract at
these doses also compared favourably (P>0.05) with the
indomethacin dosed groups. This study showed that the
aqueous and ethanolic extracts of E. chlorantha stem
bark at 50 - 200 mg/kg body weight possess antipyretic
activity and thus supports the folklore use of the plant in
the management of fever.
Key words: Enantia chlorantha, brewer’s yeast, antipyretic,
rectal temperature. |
