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Changes in haemorrheologic
and fibrinolytic activities upon hypertension and diabetic
chemotherapy in Calabar diabetic residents, Nigeria
M. S. Edem, A. O. Emeribe and J. O. Akpotuzor*
Department of Heamatology, University of Calabar Teaching
Hospital, Calabar, Cross River State, Nigeria.
*Corresponding author. E mail:
akpotuzor@yahoo.com. Tel: 08037134757.
Accepted 16 December, 2009 |
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This
research was carried out to assess the effect of
hypertension on haemorrheologic and fibrinolytic activities
in fifty (50) diabetics resident in Calabar municipality and
the values obtained were compared with those of fifty (50)
age and sex-matched non diabetics in the same locality.
Relative plasma viscosity plasma fibrinogen concentration,
euglobulin lysis time and fasting blood sugar were
determined using standard methods. The relative plasma
viscosity, plasma fibrinogen concentration, euglobulin lysis
time and the fasting blood sugar values were significantly
higher in diabetics (P < 0.05) when compared with the
controls. Correlation between RPV and duration of diabetes
was positive and significant (r = 0.323, p < 0.05). Also,
correlation between fasting blood sugar and plasma
fibrinogen concentration was positive and significant (r =
0.635, p < 0.05).There was no significant increase in RPV,
PFC and ELT of type I diabetes when compared with type II
diabetes (P > 0.05). The RPV and ELT of diabetics with
hypertension was increased, but showed no significant
difference (P > 0.05) with that of those who had no
hypertension. However, the PFC of diabetics with
hypertension was significantly increased (P < 0.05) when
compared with that of the control group. The diabetics who
were on oral hypoglycaemic agents and insulin showed no
significant difference (P > 0.05) in RPV, PFC and ELT when
compared with those who were on combination therapy of oral
hypoglycaemic agents (gamily, glucophage), but there was
significant increase when RPV, PFC and ELT values were
compared with the controls (P < 0.05). This work shows that
defective rheology and poor fibrin clearing may be the
contributory factor to vascular and thrombotic complications
seen in diabetics.
Key
words:
Hypertension, haemorrheologic, fibrinolytic, diabetes
mellitus.
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