|
Synergistic effects of
glucan and resveratrol
Vaclav Vetvicka1* and Zuzana Vancikova2
1Department
of Pathology, University of Louisville, Louisville, KY
40202, USA.
21st
Medical Faculty, Department of Pediatrics, Thomayer
University Hospital, Prague, Czech Republic.
*Corresponding author. E-mail:
vaclav.vetvicka@louisville.edu.
Tel: 502-852-1612. Fax: 502-852-1177.
Accepted
12 April, 2010. |
|
Recent
data showing that glucan stimulates defense reactions in
plants through synthesis of resveratrol, led us to study the
possible synergetic effects of a glucan-resveratrol complex
on immune reactions in mice. We measured phagocytic
activity, expression of CD4 marker on spleen cells, IL-2
secretion and antibody response. In all cases we confirmed
the stimulatory effects of glucan. Resveratrol alone had
either limit or has no effect. However, a combined
preparation showed very strong synergetic effects. Our data
support further studies of these two natural
immunomodulators.
Key
words:
Glucan, resveratrol, phagocytosis, IL-2, immune reactions,
macrophage, antibody.
|
