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Full
Length Research Paper
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Captopril interferes with
some serum biochemical findings
I. A. Ibrahim1, F. S. Al-Joudi
2*, R. Waleed Sulaiman 3 and
B. Hilal AL-Saffar4
1Department
of Pharmacology, Faculty of Medicine, National University of
Malaysia, Kuala Lumpur, Malaysia.
2Faculty
of Allied Health Sciences, National University of Malaysia,
Kuala Lumpur, Malaysia.
3Department
of Clinical Laboratory Science, Faculty of Pharmacy,
University of Baghdad, Baghdad, Iraq.
4Department
of Medicine, Hospital Dr. Abdul-Majeed, Karradah, Baghdad,
Iraq.
*Corresponding author. E-mail:
fajoudi@hotmail.com.
Tel: 060 3 92897684.
Fax: 060 3 26929032.
Accepted
22 February, 2010. |
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Abstract |
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Captopril is a widely used anti-hypertensive drug that acts
by inhibiting angiotensin-converting enzyme. This work has
been carried out to investigate the
effects of captopril on some common biochemical laboratory
parametres in the sera of patients receiving the drug. For
this study, 40 subjects were included, all within the age
range of 40 to 63 years and with newly diagnosed essential
hypertension. From each patient, two samples were taken, one
immediately before the start of treatment and the second one
taken two weeks later. The control group comprised 30
apparently healthy volunteers of comparable ages and
genders. The biochemical parameters measured in the sera
were glucose, total protein (TP), urea, creatinine, total
cholesterol (TC), triglycerides (TG), liver enzymes and
creatine kinase (CK). Captopril exerted significant
increases in the obtained readings for the concentrations of
glucose, TP, urea, creatinine, TC, TG, AST and LDH. The
increases in readings in the biochemical parameters may be
attributable to chemical or to physical interactions. They
could also be induced by physiological, enzymatic or by
in vivo metabolic factors. By all means, these
alterations that accompany captopril treatment must be taken
into account by physicians and laboratory workers, to help
avoid misinterpretation of laboratory data.
Key
words:
Captopril, biochemical laboratory tests, drug interactions. |
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