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Evaluation of
micronutrients level and antinociceptive property of
Eremostachys laciniata (L) Bunge
Salimullah Khan1,2*, Muhammad Nisar2,3,
Shabana Usman Simjee4, Wajid Rehman5,
Razaullah Khan6, Irfanullah Jan7 and
Dure-Shahwar Momin4
1Department
of Pharmacy, Hazara University Havelian, Abbottabad -22010,
Pakistan.
2Department
of Pharmacy, University of Peshawar, Peshawar,-25120,
Pakistan.
3Institute
of Chemical Sciences, University of Peshawar,
Peshawar-25120, Pakistan.
4HEJ
International Center for Chemical and Biological Studies,
Karachi University, Karachi-75270, Pakistan.
5Department
of Chemistry, Hazara University, Mansehra-21300, Pakistan.
6Fertiliser
and Lime Research Center, Massey University,
Palmerston North-11222, New Zealand.
7NCE
Geology, University of Peshawar, Peshawar-25120, Pakistan.
*Corresponding author. E-mail:
salim41us@yahoo.com.
Tel: (00)92-992-811717 or (00)92-333-987-1231. Fax:
(00)92-992-811727.
Accepted
20 November, 2009 |
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Eremostachys laciniata
(Lamiaceae)
a rich source of structurally different flavonoids is
ignored for its micronutrients level and many biological
activities. In this study, the plant was investigated for
different micronutrients including, phosphorus (P), nitrogen
(N), boron (B), zinc (Zn) and manganese (Mn) and compared
with adequate level of micronutrients for orchid crops. The
crude methanol extract and different fractions of E.
laciniata were also investigated for in vivo
antinociceptive activity using Tail-flick model. Except for
boron, all other micronutrients investigated were well in
the limits recommended for orchid crops. Crude extract and
different fraction thereof showed excellent increase in
latency time along with certain central effect of causing
sedation, ataxia and hind limb extension. This increase in
latency time is not only due to analgesia but may be a
combined effect of sedation, ataxia and analgesia. The plant
may be a useful source in future for the isolation of
natural product with analgesic property.
Key
words:
Extract, fractions, nitrogen, orchid, analgesic. |
