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Hepatoprotective effect of
Picrorrhiza kurroa on antioxidant defense system in
antitubercular drugs-induced hepatotoxicity in rats
R. Jeyakumar1, R. Rajesh1,
D. Rajaprabhu1, B. Ganesan1,2,
S. Buddhan1, R. Anandan2*
1Vinayaka
Missions University, Ariyanoor, Salem-636308, India.
2Biochemistry
and Nutrition Division, Central Institute of Fisheries
Technology, Cochin-682029, India.
*Corresponding author. E-mail:
kranandan@email.com.
Accepted
9 January, 2008 |
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The hepatoprotective effect of the ethanol extract of
Picrorrhiza kurroa rhizomes and roots (PK) on liver
mitochondrial antioxidant defense system in isoniazid and
rifampicin-induced hepatitis in rats was investigated. In
liver mitochondria of antitubercular drugs administered
rats, a significant elevation in the level of lipid
peroxidation with concomitant decline in the level of
reduced glutathione and in the activities of antioxidant
enzymes was observed. Co-administration of PK (50 mg/kg/day
for 45 days) significantly prevented these antitubercular
drugs-induced alterations and maintained the rats at near
normal status.
Key
words:
Picrorrhiza kurroa, hepatoprotective activity. |
