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Fe (III) complex of
mefloquine hydrochloride: Synthesis, antimicrobial and
toxicological activities
Adediji, J. F.1*,
Obaleye, J. A.2, Adediran, G. O.1,
Adebayo, M. A.1 and Olayinka, E. T.1
1Department
of Chemical Sciences, Ajayi Crowther University, PMB 1066,
Oyo, Nigeria.
2Department
of Chemistry, University of Ilorin, Ilorin, Nigeria.
*Corresponding author. E-mail:
dijijohnson@yahoo.com.
Tel.: +2348035720485
Abbreviation: W,
weak; B, broad; S, strong.
Accepted
4 September, 2009 |
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As part of
the ongoing research for more effective antimalarial drug,
Fe (III) complex of mefloquine hydrochloride (antimalarial
drug) was synthesized using template method. Mefloquine was
tentatively found to have coordinated through the hydroxyl
and the two nitrogen atoms in the quinoline and piperidine
in the structure, respectively. Characterization has been
done on the basis of analytical, conductance, atomic
absorption, magnetic measurement, electronic and Infra-red
spectrometry. From analytical data, the stoichiometry of the
complex has been found to be 1:1. Infra-red spectral data
also suggest that the ligand (mefloquine) behaves as a
tridentate ligand with N:N:O donor sequence towards the
metal ion. On the basis of the above physico-chemical data
it is proposed that the complex is assigned octahedral
geometry. The antimicrobial activities of mefloquine metal
complex exhibited greater inhibition than the parent ligand.
The ligand and metal complex were screened for their
toxicological activities at the dose of 6.66 mg/kg body
weight twice daily for seven days on the alkaline
phosphatase (ALP), alanine aminotranferase (ALT) and
aspartate aminotransferase (AST) activities of rat serum,
liver and kidney. Overall, it was revealed that both
mefloquine and its metal complex might show mild toxicity
particularly on the liver and kidney.
Key
words:
Fe(III) complex, synthesis, anti-malarial drug,
antimicrobial, toxicology. |
