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Review
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Metabolic
alterations and molecular mechanism in silkworm larvae
during viral infection: A review
K. Ramesh Babu1,
S. Ramakrishna2, Y. Harish Kumar Reddy1,
G. Lakshmi1, N. V. Naidu1, S. Sadak
Basha2 and M. Bhaskar2*
1Global
Institute of Biotechnology, Himayathnagar, Hyderabad-29, A.P.,
India.
2Department
of Zoology, Sri Venkateswara University, Tirupati-517 502,
A.P., India.
*Corresponding author. E-mail:
matchabhaskar@gmail.com.
Accepted
2 February, 2009 |
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Abstract |
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Silkworm
larvae, Bombyx mori (L), is an important economic
insect and also a tool to convert leaf protein into silk.
The industrial and commercial use of silk, the historical
and economic importance of production and its application in
all over the world finely contributed to the silkworm
promotion as a powerful laboratory model for the basic
research in biology. The development and economic production
of sericulture largely and greatly depends on the metabolic
modulations and molecular mechanism of silkworm, besides its
genetic composition and immunological resistance. One of the
main reasons for decreased cocoon production is the loss due
to diseases which account for about 30%. The collection of
information on investigations related to disease prevalence
in Silkworm in different parts of the country and (or)
different seasons is highly helpful to monitor, prevent and
control them. However, such collection of data on various
diseases of silkworm in general and viral infection in
particular in world wide is very limited. Pathological
status of the diseased animal can be evaluated in terms of
symptoms resulting from the interactions between host and
pathogen which in turn depends on the degree of attack,
progress of diseases, metabolic modulations, physiological
adjustments, molecular mechanisms, and the defence immune
system of the silkworm. Such symptoms are manifested in
terms of morphological, physiological and biochemical
variations in the host body. Hence, there is a dire need to
suggest alternative remedial measures for the restoration of
sericulture output even during grasserie infection, in order
to safe guard the interest of the Seri culturists involved
in sericulture practices. An attempt has been made in the
present study to provide the relevant information related to
the intricate mechanisms involved in metabolic alterations
in silkworm larvae on grasserie infection.
Key
words:
Grasserie infection, silkworm, metabolic modulations,
nuclear polyhedrosis. |
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