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In
vitro cytotoxicity of crude alkaloidal extracts of
South African Menispermaceae against three cancer cell lines
H. De Wet1*,
G. Fouche2 and F. R. Van Heerden3
1Department
of Botany, University of Zululand, Private Bag X1001,
KwaDlangezwa, 3886, South Africa.
2Bioprospecting,
Biosciences, CSIR, P. O. Box 395, Pretoria, 0001, South
Africa.
3School
of Chemistry (Pietermaritzburg), University of
KwaZulu-Natal, Private Bag X01, Scottsville 3209, South
Africa.
*Corresponding author. E-mail:
hdewet@pan.uzulu.ac.za.
Tel: +27-35-9026108. Fax: +27-35-9026491.
Accepted 5
May, 2009 |
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The cytotoxicity of crude alkaloid extracts obtained from the
leaves and rhizomes of all the South African members of the
family Menispermaceae (seven genera and 13 species) was
tested against MCF7 (breast), UACC62 (melanoma) and TK10
(renal) cancer cell lines. Extracts of ten of the thirteen
species showed positive activity against all three cancer
cell lines with
significant inhibition of cellular growth at TGI
(total
growth inhibition)
values lower than 6.25 μg/ml for Albertisia delagoensis
and Antizoma angustifolia leaves.
Key
words:
Cytotoxicity, alkaloids, menispermaceae, South Africa. |
