|
Thyroidal angiogenesis in zebrafish (Danio rerio)
exposed to high perchlorate concentration
İşisağ Üçüncü, Sema1*,
Karayazı, Ödül 1 and İşisağ, Aydın2
1Department
of Biology, Faculty of Science, Ege University, 35100
Bornova, İzmir, Turkey.
2Department
of Pathology, Faculty of Medicine, Celal Bayar University,
Manisa, Turkey.
*Corresponding author.
E-mail:
sema.isisag@ege.edu.tr.
Accepted 10 April, 2009 |
|
As a well known environmental
contaminant, perchlorate inhibits thyroidal iodide uptake
and reduces thyroid hormone levels. In zebrafish (Danio
rerio) exposed to high concentrations of sodium
perchlorate (200, 350 and 500 mg/L) for 10 days, remarkable
angiogenesis was identified, not only histopathologically
but also statistically by counting of the small, medium and
large sized (grades 1 to 3) vessels per unit area.
Angiogenic response is concluded as the most sensitive
parameter for rating of high concentrations of perchlorate
exposure.
Key words:
Perchlorate, zebrafish, thyroid, angiogenesis. |
