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Relationships between the
molecular structure and moisture-absorption and
moisture-retention abilities of succinyl chitosan
Guo Qing Ying, Hao Yang*,
Yu Yi and Feng Xu
College
of Pharmaceutical Science, Zhejiang University of
Technology, Hangzhou 310032, China.
*Corresponding author. E-mail:
yanghao82214@126.com
Tel:
86-0571-88320320-802.
Accepted 21 March, 2007 |
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N-Succinyl
chitosan (NSC) with various degrees of deacetylation (DD 6 –
94%) and substitution (DS 0.14 – 0.79) were successfully
prepared from N-acetylchitosans in varying reaction
time. Infrared spectroscopy (IR), 1H NMR and
gel-permeation chromatographic (GPC) techniques were used to
characterize their molecular structures. The
moisture-absorption (Ra) and -retention (Rh)
abilities of NSC are closely related to the DD and DS
values. Under conditions of high relative humidity, the
maximum Ra and Rh were
obtained at DD values of about 50%, and when the DD value
deviated from 50%, Ra and Rh
decreased. Under dry conditions, when the DD value was 50%,
the Rh was the lowest. The NSC with DS
0.65 to 0.79 exhibited better Rh than that
of HA, and has the potential to prepare HA-like substances
in pharmaceutical and cosmetics industries.
Key
words:
Chitosan, moisture-absortion, moisture-retention and
succinic anhydride. |
