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Antidiabetic activity of
water extract of Solanum trilobatum (Linn.) in
alloxan-induced diabetes in rats
A. Doss1, M.
Palaniswamy2, J. Angayarkanni3 and R.
Dhanabalan1*
1Department
of Microbiology, RVS College of Arts and Science,
Coimbatore, Tamilnadu, India.
2Department
of Microbiology, Karpagam Arts and Science College,
Coimbatore, Tamilnadu, India.
3Department
of Biotechnology, Bharathiyar University, Coimbatore,
Tamilnadu, India.
*Corresponding author. E-mail:
bharathi.dhanabalan@gmail.com.
Tel.: (0422) 2687603, 2687421, 2687480.
Accepted
16 April, 2008 |
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The
antidiabetic potential of the water extract of Solanum
trilobatum L. (Solanaceae), a medicinal plant widely
used in the traditional Ayurveda and Siddha systems of
medicine for the treatment of diabetes mellitus was
evaluated in the alloxan monohydrate induced diabetic model.
Graded doses of the water extract were administered to
normal and experimental diabetic rats for 10 days.
Significant (p < 0.05) reduction in fasting blood
glucose levels were observed in the normal as well as in the
treated diabetic animals. Serum insulin levels were not
stimulated in the animals treated with the extract. In
addition, changes in body weight, serum lipid profiles and
liver glycogen levels assessed in the extract treated
diabetic rats were compared with diabetic control and normal
animals. Significant results were observed in the estimated
parameters, thereby justifying the use of the plant in the
indigenous system of medicine.
Key
words:
Antidiabetic
activity, alloxan monohydrate, Gliben clamide, rats,
Solanum trilobatum |
