|
In vitro
trypanocidal effect of methanolic extract of Sclerocarya
birrea, Commiphora kerstingii and Khaya senegalensis
H. G. Mikail
Department
of Pharmacology and Toxicology, Faculty of Veterinary
Medicine, University of Abuja, Nigeria. E-mail:
mghudu@yahoo.com.
Accepted
16 February, 2009 |
|
The anti-trypanosomal activity of methanolic extract of
Sclerocarya birrea, Commiphora kerstingii and Khaya
senegalensis were evaluated against Trypanosoma brucei
brucei in vitro at concentrations of 2 and 4 mg/ml.
Susceptibility of the organism was determined in culture
medium containing 5% dextrose and 0.9% saline solution alone
as control and 2 and 4 mg/ml of these plants extracts in the
same solution. Complete mortality of the organism was
observed at almost all the concentrations within 30 min; the
organism however survived for almost 3 h in the control test
tube. The result suggests that S. birrea, C. kerstingii
and K. sengalensis extracts may possess some
trypanocidal principles which may require further
elucidation.
Key
words:
Trypanosomosis, trypanosome, medicinal plant. |
