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Antiproliferative hepari
(glycosaminoglycans) isolated from giant clam (Tridacna
maxima) and green mussel (Perna viridis)
Muthuvel Arumugam1*,
Hari Garg2, Thangappan Ajithkumar1 and
A. Shanmugam1
1Centre
of Advanced study in Marine Biology, Annamalai University,
Portonovo, India.
2Pulmonary
and Critical Unit, 148 Bulfinch, Mass General Hospital,
Boston, MA 02114, USA.
*Corresponding author. E-mail:
aru_hep@yahoo.com.
Accepted
8 October, 2007 |
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Heparin was isolated from two bivalve mollusks, Tridacna
maxima (giant clam) and Perna viridis (green
mussel). The isolated heparin was quantified in crude as
well as purified samples and they were estimated as 2.72 and
2.2 g/kg (in crude) and 260 and 248 mg/g (in purified
samples) in T. maxima and P. viridis,
respectively. The antiproliferative activity of both the
samples performed with pulmonary artery smooth muscle cells
(PASMC) indicate a dose dependent manner. Among these two
clams, P. viridis heparin showed higher
antiproliferative activity than that of T. maxima.
Key
words:
heparin, antiproliferative activity, giant clam, green
mussel, glycosaminoglycan. |
