|
The research progress of
MSCs proliferation and differentiation in bone injury
according to the TCM theory
Liu Yang, Hai-Ying Sun*, Tao Sun and Nian-Min Qi
School of
Pharmacy, Shanghai Jiaotong University, Shanghai 200240,
China.
*Corresponding author. E-mail:
hysun@sjtu.edu.cn.
Tel: +86-21-34205437. Fax: +86-21-34204746.
Abbreviations:
TCM, Traditional Chinese medicine; MSC, mesenchymal stem cell; NSE,
neuron specific enolase; GFAP, glial fibrillary
acidic protein; GSB, a TCM drug called Gui-Si-Bu;
ALP, alkaline phosphatase; TGF-β, transforming
growth factor-β; BMP-2, bone morphogenetic protein 2;
RT-PCR, real-time polymerase chain reaction; DR,
Drynariae Rhizoma; MHC, major histocompatibility
complex; BEAs, blood enrichers and activators; NF,
neurofilament; BCBC, bovine cancellous bone complex;
CTPM, Chinese-Traditional-Patent-Medicine; DQTMP,
a TCM medicine called Dan-Qi-Tong-Mai-Pian.
Accepted 7
January, 2009 |
|
Chinese have enjoyed not only quick recovery from but also
effective daily prophylaxis of bone injuries. According to
the Traditional Chinese Medicine (TCM) theory, Shen (or
nephridium) is in charge of the bone, which corresponds to teeth,
spine, skull, femur and the like. The function of Shen can
be divided into Shen Yin (or negative nephridium) and Shen
Yang (or positive nephridium). Bone injury is usually
accompanied with blood stasis and loss in microenvironment.
Therefore, traditional Chinese doctors had chosen tonifying
Shen Yin, invigorating Shen Yang, enriching and activating
the blood or even combining the above three strategies for
injured bone repairing. Nowadays, researchers are
reunderstanding TCM drugs and formulas by studying
mesenchymal stem cells (MSCs) proliferation and
differentiation in vitro and vivo. This review
will introduce some newest articles mainly in China focusing
on the growth and differentiation of MSCs, which were
treated with a single herb or formulas of those drugs
(belonging to the above four classes) to demonstrate the
huge potential of TCMs in the future bone-injury-therapeutic
production of MSCs.
Key
words:
MSC,
traditional chinese medicine, osteogenic differentiation,
bone injury repairing. |
