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Preparation and
antidiabetic activity of polysaccharide from Portulaca
oleracea L.
Fenglin Li1,3, Qingwang Li1,2*,
Dawei Gao1, Yong Peng 1 and Caining
Feng2
1Department
of Biological Engineering, College of Environment, Chemical
Engineering, Yanshan University, Qinhuangdao, Hebei
Province, 066400, People’s Republic of China.
2College
of Animal Science, Northwest Agriculture and Forestry
University Y*-angling, Shanxi Province 712100, People’s
Republic of China.
3Department
of Bioengineering, Jilin Agricultural Science and Technology
College, Jilin, Jilin Province, 132101, People’s Republic of
China.
*Corresponding author.
E-mail: swgclfl@163.com or
ysulqw@126.com. Tel.: +8613630657638.
Accepted
6 February, 2009 |
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Extraction
parameters of polysaccharide from Portulaca oleracea
L. (POP) and antidiabetic activity of POP on alloxan
induced diabetic mice
were
studied.
Better
extraction parameters of
POP
were
obtained by
the
single factor test,
as follows: extraction temperature
95°C,
extraction time
5 h,
and ratio of solvent to raw material
40. POP
treatment (200, 400 mg/ kg body weight)
for 28
days
resulted in a significant decrease in the concentration of
fasting blood glucose (FBG),
total
cholesterol (TC)
and
triglyceride (TG)
in diabetes mellitus mice. Furthermore,
POP
significantly increased the concentration of high-density lipoprotein cholesterol (HDLc)
and
serum insulin level
in diabetes mellitus mice. Our data demonstrated
POP
at the dose of 400 mg/kg body weight (bw) exhibited optimal
effect. The above results suggest that
polysaccharide
extracted from
P. oleracea
L.
can
control blood glucose and modulate the metabolism of glucose
and blood lipid in diabetes mellitus mice.
Key
words:
Extract, Portulaca oleracea L., polysaccharide,
antidiabetic. |
