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Comparative study of the
hypoglycemic effects of coconut water extract of
Picralima nitida seeds (Apocynaceae) and Daonil in
alloxan-induced diabetic albino rats
Salihu M. Ajao1, Luqman A. Olayaki2,
Oshiba O. J.1, Rabiu O. Jimoh1, Sikiru
A. Jimoh1, Ayokunle Olawepo1 and
Adesola I. R. Abioye1
1Department
of Anatomy, Faculty of Basic Medical Sciences, College of
Health Sciences, University of Ilorin, Ilorin, Nigeria.
2Department
of Physiology, Faculty of Basic Medical Sciences, College of
Health Sciences, University of Ilorin, Ilorin, Nigeria
*Corresponding author. E-mail:
moyoajao@yahoo.com.
Accepted
15 January, 2009 |
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The study was designed to compare the hypoglycemic effects of
coconut water extract of Picralima nitida seeds to
that of Daonil in alloxan-induced diabetic albino rats.
Twenty five albino rats weighing between 170 - 200 g were
randomly divided into five groups after allowing the rats to
acclimatize for seven days and were made diabetic by
intraperitoneal administration of 150 mg/kg of alloxan. The
rats were giving different volumes of the extract and Daonil
as per their groupings. All the substances were given for
five days by oro-gastric tube. The blood glucose level were
measured daily in the rats. There was an initial inactivity
in the rats following administration of the extract mixture
and their appetite was low except for the control group. The
blood glucose levels (in mmols/dL) of the rats at the start
and end of the experiment for the groups were: control (9.6
± 0.1 to 9.2 ± 0.1), coconut water only (11.5 ± 0.3 to 6.2 ±
0.1), aqueous extract of P. nitida seeds (12.4 ± 0.1
to 5.8 ± 0.2), coconut water extract of P. nitida
seeds (11.8 ± 0.2 to 4.2 ± 0.1), and Daonil (10.5 ± 0.4 to
4.3 ± 0.1). Therefore, coconut water extract of P. nitida
seeds have a significant hypoglycemic effects in alloxan-induced
diabetes comparable to that of the Daonil, hence, it could
be an effective adjunct in the management of diabetes
mellitus.
Key
words:
Albino rats, alloxan, coconut water, Daonil, diabetes
mellitus, Picralima nitida. |
