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Phytochemical and
antimicrobial screening of the crude extracts from the root,
stem bark and leaves of Bridelia ferruginea
E. A. Adebayo1* and O. R. Ishola2
1Department
of Pure and Applied Biology, Ladoke Akintola University of
Technology, Ogbomoso, Nigeria.
2Department
of Biological Sciences, Covenant University, Otta, Ogun
State, Nigeria.
*Corresponding author. E-mail:
brogoke2003@yahoo.com.
Tel: 2348038099092.
Accepted
12 December, 2008 |
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The root, stem bark and leaves of Bridelia
ferruginea, which have some ethnomedicinal applications
were investigated for their action against some disease
causing microorganisms. Phytochemical screening revealed the
presence of alkaloids, tannins, saponins, steroids,
flavonoids, anthraquinones and phlobatannins (mostly in root
and stem bark). The antimicrobial screening of the crude
methanol extract carried out in vitro had wide range
of activity on Salmonella typhi, Escherichia coli,
Staphylococcus aureus, Proteus mirabilis and
Candida albicans. The crude root extracts inhibited the
growth of E. coli, S. aureus, S. typhi, P.
mirabilis and C. albicans at concentrations of 40
, 100, 60, 60, and 80 mg/ml respectively, while the stem
bark had minimum inhibitory concentration (MIC) of 60 mg/ml
on S. typhi and 10 mg/ml on C. albican. The
extract from leaf had no antimicrobial activity against any
of the clinical isolates used for this work. The findings
indicate that the extracts from root contain the most active
components.
Key
word:
Bridelia ferruginea, phytochemical, antimicrobial
agent, crude extract, minimum inhibitory concentration. |
