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Comparative study of some
mechanical and release properties of paracetamol tablets
formulated with cashew tree gum, povidone and gelatin as
binders
Okoye, E. I.1*, Onyekweli, A. O.1,
Ohwoavworhua, F. O.2 and Kunle, O. O.2
1Department
of Pharmaceutics and Pharmaceutical Technology, University
of Benin, Benin City, Nigeria.
2Department
of Pharmaceutical Technology and Raw materials Development,
National Institute for Pharmaceutical Research and
Development (NIPRD), Idu, Abuja.
*Corresponding author. E-mail:
ebypiaen@yahoo.com.
Tel: +23408052742521
Accepted
12 February, 2009 |
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The mechanical and release properties of paracetamol tablets
formulated with cashew gum (CAG), povidone (PVP) and gelatin
(GEL) as binders were studied and compared. The parameters
studied were tensile strength (TS), brittle fracture index
(BFI), friability (F), disintegration time (DT) and
percentage drug released (PDR). Results showed that the TS
and BFI values of tablets formulated with CAG were the
lowest at all binder concentrations. The friabilities of all
formulations were within accepted limits (<1.0%).
Disintegration times were longest for GEL formulated tablets
and least for PVP formulated ones. At binder concentrations
of 1.0 – 3.0% (w/w) CAG released the highest cumulative
amount of drug in 30 min; from 4.0 – 5.0% (w/w) cumulative
amount released became highest for PVP formulated tablets.
GEL formulated tablets generally released the least amount.
CAG gum therefore having imparted better BFI than PVP or
GEL, and does not hinder drug release is strongly
recommended as an alternative to the more expensive PVP or
GEL for immediate release tablet formulations.
Key
words:
Cashew gum, povidone, gelatin, binder, mechanical, release
properties of paracetamol tablets. |
