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Biochemical studies on
the effect of curcumin and embelin during N-nitrosodiethylamine/phenobarbital
induced-hepatocarcinogenesis
in wistar rats
M. C. Jagadeesh*, M. Sreepriya, Geetha Bali and D.
Manjulakumari
Department
of Microbiology and Biotechnology, Bangalore University,
Jnanabharathi Campus, Bangalore-560 056, Karnataka, India.
*Corresponding author. E-mail:
jagabiotech@gmail.com
Accepted
5 June, 2009 |
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The biochemical effects of administration of embelin a
benzoquinone derivative from Embelia ribes and
curcumin (diferuloyl methane) isolated from Curcuma longa
against a 2 step
hepatocarcinogenic regimen comprising of N-nitrosodiethylamine
(DENA)/phenobarbital (PB) was studied in wistar strain male
albino rats with respect to lipid profile, renal function
tests and levels of blood glucose. Rats administered DENA/PB
showed hyper cholesterolaemia, hyper triglyceridaemia,
elevated low-density lipoproteins (LDL), free fatty acids (FFA),
very-low-density lipoproteins (VLDL) levels and decreased
urea levels. Pre- and co-treatment with embelin and curcumin
for 14 weeks significantly prevented the biochemical
alterations induced by DENA/PB. Results of our study suggest
the protective and hypolipidemic effects of embelin and
curcumin during chemically- induced hepatocarcinogenesis in
wistar rats.
Key
words:
Embelin, curcumin,
N-nitrosodiethylamine,
phenobarbital, cholesterolaemia, triglyceridaemia. |
