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Application
of an antibacterial dressing spray in the prevention of
post-operative infection in oral cancer patients:
A
phase 1
clinical trial
Yizhou Zeng1,
Runzhi Deng1*, Barry, H.S. Yeung2,
Wings T.Y. Loo3, Mary N.B. Cheung3,
J.P. Chen3, Bingrong Zhou1, Yifu Fu1,
Lanzhu Huang1, Mingxing Lu1 and
Min Wang4
1Department
of Oral Maxillofacial Surgery, Nanjing Stomatological
Hospital, Nanjing, China.
2Department
of Microbiology, Immunology and Molecular Genetics, the
University of California Los Angeles, USA.
3School
of Chinese Medicine, the University of Hong Kong, Hong Kong.
4Department
of Prosthodontics, West China College of Stomatology,
University of Sichuan, Chengdu, P.R. China.
*Corresponding author. E-mail:
wtyloo@163.com.
Accepted
8 October, 2008 |
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This study investigates the effects on the prevention of oral
infection after operation in oral region by using
an
antibacterial dressing spray (JUC spray). 60 patients diagnosed with grade 1 and 2 of oral squamous
cell cancinoma, and the conservation surgery had applied to
them under general anesthesia. Half of these patients were
treated with JUC and the rest accepted traditional method.
The complete blood picture (CBP) and the growth of bacteria
in the wound were analyzed. The average wound healing time
in JUC group was significantly shorter than that in the
control group. The amount of bacteria presented in wound was
lower in JUC group than that in the traditional group. There
was no significant difference between the CBP of the two
groups. The JUC
antibacterial dressing spray,
after spraying on the surface of the wound formed a layer of
physically antibacterial molecular film to prevent the
growth of bacteria and effectively reduced the average wound
healing time.
Key
words:
Antibacterial dressing spray, oral squamous cell cancinoma,
wound healing, infection. |
