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Pattern of
multi-drug resistant Salmonella enterica
serovar typhi isolates in Nigeria
Ijeoma Gladys Kalu*, Toochukwu Ekwutos
Ogbulie and F. N. Opara
Department of Biotechnology, Federal Univesity of
Technology, Owerri, Nigeria.
*Corresponding author. E-mail:
olaedo_k@yahoo.com.
Tel: +2348033459499.
Accepted 28 May, 2008 |
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Typhoid fever continues to remain a health problem as the
causative organism, Salmonella enterica
serovar typhi, has developed resistance to many antibiotics
used. This study was undertaken to determine the current
pattern of resistance to antimicrobial agents by S.
enterica serovar typhi isolates from Akaraugo Hospital
in Owerri, Imo state. Sensitivity to most common
antimicrobial agents used in the management of typhoid fever
was determined by disc diffusion according to National
Committee for Clinical Laboratory (NCCL) standards. There
was an increase in the number of isolates with decreased
sensitivity to nalixidic acid and cotrimoxazole. All
isolates had complete resistance to augmentin, tetracycline
and amoxicillin commonly used for treatment of typhoid
fever. Therefore physicians should be advised to conduct
effective susceptibility test before prescribing an
antibiotics to a patient. It is also important to step up
awareness to individuals about indiscriminate use of
antibiotics and the need to complete a regime once it is
started.
Key word:
Typhoid fever, antibiotic susceptibility, Salmonella
enterica serovartyphi.
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