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The bioactive and
phytochemical properties of Garcinia kola (Heckel)
seed extract on some pathogens
Adegboye, M. F.1,
Akinpelu, D. A. 1,2* and Okoh, A. I.2
1Department
of Microbiology, Obafemi Awolowo University, Ile Ife,
Nigeria.
2Applied
and Environmental Microbiology Research Group (AEMREG),
Department of Biochemistry and Microbiology, University of
Fort Hare, Private Bag X1314, Alice 5700, South Africa.
*Corresponding author. E-mail:
DAkinpelu@ufh.ac.za.
Accepted
29 August, 2008 |
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In vitro antimicrobial activities of crude extract of Garcinia kola was
investigated against some bacterial isolates comprising of
both Gram-positive and Gram-negative organisms. The
methanolic crude extract exhibited significant inhibitory
action against eleven out of fifteen bacterial isolates
tested at a final concentration of 20 mg/ml. The zones of
inhibition exhibited by the extract against the tested
organisms ranged between 10 and 23 mm, while the zones of
inhibition exhibited by streptomycin and tetracycline used
as standard antibiotics ranged between 15 and 25 mm; 12 and
25 mm respectively. On the other hand, the minimum
inhibitory concentrations exerted by the extract against the
bacterial isolates ranged between 0.079 and 5.00 mg/ml while
the ranged exhibited by streptomycin was between 0.0157 and
0.50 mg/ml. The plant extract compared favourably with the
two standard antibiotics used in this study. The following
phytochemical compounds were present in the plant extract:
flavonoids, tannins, cardiac glycoside, saponins, steroids
and reducing sugars.
Key words: Garcinia kola, antimicrobial activity, minimum
inhibitory concentrations, phytochemical compounds.
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