African Journal of Biotechnology Vol. 7 (1), pp. 012-015, 4 January 2008   

ISSN 1684–5315 © 2008 Academic Journals        

Full Length Research Paper

Extracts from Aloe ferox and Withania somnifera inhibit Candida albicans and Neisseria gonorrhoea

L. Kambizi¹* and A.J. Afolayan²

¹Walter Sisulu University, Biological Sciences Department, P. Bag X1 Mthatha 5117, South Africa.

²Fort Hare University, Botany Department, Alice 5700, South Africa.

*Corresponding author. E-mail: Lkambizi@wsu.ac.za.

Accepted 14 November, 2007

Herbal medicines play a vital role in the treatment of sexually transmitted infections (STIs), especially in the remote areas of South Africa where clinics and hospitals are sparsely located. Aloe ferox and Withania somnifera are among the southern African plants commonly used for the treatment of (STIs). This paper reports on the in vitro antimicrobial activities of water and methanol extracts from the two plants on Neisseria gonorrhoea and Candida albicans, common causes of STIs in rural South Africa. Extracts from both species together with pure aloin from A. ferox, were evaluated for activity against six strains of N. gonorrhoea and nine strains of C. albicans. The extracts showed activity against N. gonorrhoea at concentrations of ranging from 0.5 (methanol extracts from both) to 10 (water extract of W. somnifera only) mg/ml while pure aloin inhibited the growth of both microorganisms. Only the methanol extract of W. somnifera was effective against C. albicans at a concentration of 20 mg/ml.

Key words: Antimicrobial, Aloe ferox, Candida albicans, Neisseria gonorrhoea, Withania somnifera.