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Antibacterial activity and
cytotoxicity of essential oil of Lantana Camara
L. leaves from Nigeria
O. Oluwadayo Sonibare* and I. Effiong
Chemistry Department, University of Ibadan, Nigeria.
*Corresponding author.
E-mail:
sonibaredayo@yahoo.com.
Accepted
18 June, 2008 |
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The chemical composition of essential oil obtained from
air-dried leaves of Lantana camara L. by
hydrodistillation was analyzed by GC and GC-MS. A total of
thirty-two compounds representing 74.8% of the oil were
identified. The main constituents were 1,8-cineol (15.8%),
sabinene (14.7%) and β-caryophylene (8.9%). The essential
oil was tested for antibacterial activity against 6 strains,
using disc diffusion method, and for cytotoxicity using
brine-shrimp lethality assay. The oil showed moderate
activity against
Candida albican,
Bacillus subtilis, Staphylococcus typhi,
Pseudomonas aeruginosa
and Bacillus aureus. These activities support its
potential use as a remedy for bacterial infectious
diseases. The essential oil with LC50 value of 0.01 was
found to be highly toxic.
Key
words:
Lantana camara
L,
antimicrobial, cytotoxicity, essential oil,
1,8-cineol,
sabinene. |
