Review

Properties of glucoside 3-dehydrogenase and its potential applications

Li-Qun Jin and Yu-Guo Zheng*

Institute of Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, Zhejiang Province, People’s Republic of China.

*Corresponding author. E-mail: zhengyg@zjut.edu.cn.  Tel: +86-571-88320379. Fax: +86-571-88320630.

Accepted 1 December, 2008

Glucoside 3-dehydrogenase, one of the glucose redoxidases, is perhaps known for the vital role it plays in converting a series of sugars to their corresponding 3-ketoglucosides. Glucoside 3-dehydrogenase has attracted considerable attention in recent years due to broad substrate specificity and excellent regioselectivity. Glucoside 3-dehydrogenase is a FAD-enzyme, which is capable of oxidizing glucosides and galactosides to their corresponding 3-ketoglycosides, due to the enzyme’s site-selective oxidation of the C-3 hydroxyl group. These 3-ketoglucosides are useful as building blocks for chemicals such as detergents and polymers. The versatile glucoside 3-dehydrogenase has potential applications in different fields including sugar industry, clinical diagnosis and pharmaceutical intermediates synthesis. This review attempts to describe the glucoside 3-dehydrogenase concerning the sources, properties and applications in detail.

Key words: Glucoside 3-dehydrogenase, application, 3-ketoglucoside.