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Antitumor and antioxidant
potential of Tragia Plukenetii R.Smith on Ehrlich
ascites carcinoma in mice
Meenakshi Sundaram Muthuraman1*, Sudarsanam
Dorairaj2, Parthasarathy Rangarajan3
and Brindha Pemaiah3
1Department
of Biotechnology, Srimad Andavan Arts and Science College,
No.7, Nelson Road, T.V.Koil, Trichy - 620 005, Tamil Nadu,
India.
2Department
of Advanced Zoology and Biotechnology, School of Genomics,
Loyola College, Nungambakkam, Chennai – 600 034, Tamil Nadu,
India.
3Department
of Biosciences, Srimad Andavan Arts and Science College,
No.7, Nelson Road, T.V.Koil, Trichy – 620 005, Tamil Nadu,
India.
*Corresponding author. E-mail:
msundar77@yahoo.com.
Tel: +91-9894475375.
Accepted
29 August, 2008 |
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This investigation aims to evaluate the antitumour and
antioxidant potential of the ethanol extract of Tragia
Plukenetii R.Smith (ETP) on Ehrlich ascites carcinoma (EAC)
tumor model. Tumor was induced in mice by intraperitoneal
injection of EAC cells (2x106 cells/mouse).
Ethanol extract of T. Plukenetii (ETP) was
administered to the experimental animals at the dose levels
of 100, 200 and 300 mg/kg/day after 24 h of tumour
inoculation. The antitumour effect of ETP was evaluated by
assessing in vitro cytotoxicity, survival time,
hematological and antioxidant parameters. Oral
administration of ETP increased the survival time of the EAC
bearing mice. The ETP brought back the altered levels of the
hematological and antioxidant parameters in a dose dependent
manner in EAC bearing mice. The results were comparable to
that of the result obtained from the animals treated with
the standard drug 5-flurouracil (20 mg/kg.bw). Thus present
study revealed that ETP possessed significant antitumor and
antioxidant activity.
Key
words:
Tragia Plukenetii, Ehrlich ascites carcinoma,
hematological parameters, antioxidant, tumour growth
response. |
