Full Length Research Paper

Preventive effect of ordinary and hyperimmune bovine colostrums on mice diabetes induced by alloxan

Daodong Pan^{1, 2}* and Haiyan Liu¹

¹Department of Food Science and Nutrition, Nanjing Normal University, Nanjing 210097, P.R. China.

²Life Science and Biotechnology Faculty of Ningbo University, Ningbo 315211, P.R. China.

*Corresponding author. E-mail: daodongpan@163.com. Tel: + 86 - 25 – 83598286. Fax: + 86 - 25 - 83707623.

Accepted 28 October, 2008

In the present study, the anti-diabetic effect of ordinary and hyperimmune bovine colostrum were evaluated in diabetic mice induced by alloxan. The results indicated that blood glucose levels were significantly decreased after administration of colostrum for 30 d, and the glucose tolerance was strengthened in a dose-dependent manner. In addition, the hyperimmune colostrum was more efficient than ordinary colostrum in decreasing the blood glucose level and improving glucose tolerance in diabetic mice (P<0.05). Furthermore, total levels of serum cholesterol (TC) and triglycerides (TG) were significantly decreased, and serum high density lipoprotein cholesterol (HDL-c) was significantly increased in a dose-dependent manner compared with the control; the hyperimmune colostrum was also more efficient than ordinary colostrum in reducing the serum levels of TC and TG, and increasing the serum levels of HDL-c in diabetic mice (P<0.05). These results suggest that bovine colostrum could modify the diabetic phenotype of mice induced by alloxan.

Key words: Colostrum, diabetic mice, blood glucose, blood lipids.